Association of hepatocellular carcinoma with thiazolidinediones use

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

Association of Metformin Use With Cancer-Specific Mortality in Hepatocellular Carcinoma After Curative Resection

Many preclinical reports and retrospective population studies have shown an anticancer effect of metformin in patients with several types of cancer and comorbid type 2 diabetes mellitus (T2DM). In this work, the anticancer effect of metformin was assessed in hepatocellular carcinoma (HCC) patients with T2DM who underwent curative resection.A population-based retrospective cohort design was used...

Association of interleukin-6 polymorphisms with susceptibility to hepatocellular carcinoma.

TARGET Our study was to investigate the effects of interleukin-6 (IL-6) polymorphisms (rs2069837 and rs17147230) on the risk for hepatocellular carcinoma (HCC). METHODS A total of 226 HCC cases and 220 healthy controls were admitted into the study and genomic DNA was extracted from the peripheral blood. The genotyping was conducted by the method of polymerase chain reaction-restriction fragme...

Association of NQO1 and ESR1 polymorphisms with hepatocellular carcinoma susceptibility

Aims: With the purpose of investigating the association between NQO1 and ESR1 polymorphisms and the susceptibility to hepatocellular carcinoma (HCC), and providing scientific basis for the prevention and treatment of the disease, this case-control study was designed. Methods: The genotypes of NQO1, ESR1 gene polymorphisms were detected by polymerase chain reaction-restriction fragment length po...